| Osteoporosis Drugs, May Raise Risk Of Unusual Thigh Bone Fractures |
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The authors stress that atypical femur fractures are very uncommon, and only represent approximately 1% of high and thigh fractures. In response to growing concern about bisphosphonates and their link to unusual thigh bone (femur) fractures, the American Society of Bone and Mineral Research convened a task force. The U.S. FDA (Food and Drug Administration) said earlier on this year that it would wait for the report to come out before deciding on recommendations regarding bisphosphonates.Task force co-chair and lead author Elizabeth Shane, M.D., of Columbia University, said, "For the vast majority of patients with osteoporosis, these drugs are an important weapon against fractures and their benefits far outweigh the risks of using them. Most of the patients who experienced these atypical femur fractures had been taking bisphosphonates for more than five years. However, we are concerned that there may be a relationship between these fractures and long-term bisphosphonate use and, although the risk is low, we want to make sure that people know about the warning signs." The task force is calling for:
The task force, consisting of experts from various countries and a variety of medical areas, carried out an extensive review of both published and unpublished data. They also interviewed researchers who work in companies that make and sell these drugs. They interviewed FDA staff - the FDA maintains a database that tracks reported side effects for approved drugs (MedWatch). The researchers revealed that there appears to be a lack of awareness regarding atypical femur fractures, as well as their warning signs. Awareness also seems to be lacking regarding the link between bisphosphonates and thigh bone fractures. Bisphosphonates, which have been used by millions of osteoporosis patients, mostly women, were approved in 1995. They include the following brand names:
Osteoporosis, as well as other bone diseases, can have a drastic effect on a person's functions. Broken bones caused by osteoporosis can cause severe pain, loss of height, stooped posture, and breathing problems.
Health professionals should reserve bisphosphonates for patients with certain cancers, Paget's disease of bone, and patients with osteoporosis who are at high risk of having a fracture. Drug labels should include information about this side effect. Although the risks are very low, health professionals should know the warning signs of atypical femur fractures and regularly ask patients on these drugs about groin or thigh pain. They also should assess annually whether this therapy is appropriate for each patient." T.S. Wiley notes, "Osteoporosis affects women eight times more than men. One in two women over the age of fifty will suffer at least one lifetime fracture from osteoporosis. When we run out of estrogen and "So the treatment answer is simple. Natural, "Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the American Society for Bone and Mineral Research Authors" |
Osteoporosis patients who take bisphosphonates, a widely prescribed class of drugs which is very effective in lowering bone fractures, may increase the risk ofatypical femur fractures - unusual but serious thigh bone fractures - if the medication is taken long term, a study revealed. The study, authored by a Task Force has been published in the medical journal Journal of Bone and Mineral Research.
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