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The Wiley Protocol® is a trademarked, patent protected bio-identical hormone replacement therapy (HRT) delivery system consisting of biomimetic estradiol and progesterone in a topical cream preparation -- dosed to mimic the natural hormones produced by a woman’s body when she was in her prime.The Wiley Protocol is multi-phasic rhythmic dosing, meaning that the topical creams are administered via measurable plunger applicators and their amounts vary throughout the 28 day cycle to restore the hormone levels.